I've realized there are two things that can keep me reading: tension, and anticipation. The best stories provide a combination of both, though different people prefer more tension (tragedy) or more anticipation (comedy). I, personally, prefer anticipation -- which makes sense, seeing as I like to write comedy. I don't think one form of storytelling is "better" than another, but I do think it's a betrayal to your audience to start with a radically different combination than you started with.
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