Loretta and Reg have always had a "buddy" type of relationship. A lot of times in stories, you'll find a girl who hangs out with guys angsting about being considered "one of the guys" because she have a crush on one of them, and he doesn't think of her as a girl. Sure, that does happen in real life, but it's way overdone in stories. I never had a crush on any of my guy friends in school -- they were always just friends. That's how things are with Loretta and Reg.
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